Lateral temporal atrophy is a better visual scale to predict MMSE score than hippocampal atrophy in Alzheimer’s disease: A retrospective cross‐sectional study

Background Mini-Mental State Exam (MMSE) is helpful in the cognitive evaluation and staging of Alzheimer patients (AD), but its score could be affected by acute medical conditions, depression, or anxiety. Conversely, head magnetic resonance imaging (MRI) an independent diagnostic tool to evaluate specific cerebral pathology AD patients. Many studies have investigated correlation between MRI visual scales such as hippocampal atrophy baseline MMSE aid diagnosis AD. However, there has not been a study that evaluates comprehensive scale with Method We retrospectively collected records outpatients diagnosed probable according DSM V criteria two dementia wards. Patients age onset before 65 years old were considered early-onset The rating (CVRS) was used semiquantitative structural lesions, including hippocampal, cortical, subcortical atrophy, small vessel disease. relationship lesions evaluated using Bayesian model averaging (BMA) control confounders. Data analysis done R-4.0.3. Result 21 (32.31%) Lateral temporal level education, late age-onset strongest predictors MMSE, while other significant BMA model. Furthermore, only correlated delayed recall, orientations, attentions, language, visual-spatial. Conclusion Our suggests lateral correlates more than atrophy.